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There are many potential processes underlying MTX toxicity (Reference Chan and Cronstein33) , but no effective treatments to ameliorate the condition exist

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If DPP-4 inhibitors exert any effect to inhibit sodium transport in the proximal tubule, this action does not appear to be mediated by potentiation of GLP-1 and or by pathways linked to the GLP-1 receptor [98,99,100,101]

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