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Authors: Karen G Farrar University of Southern California , Los Angeles, CA, Duy Do Truveta, Inc , Bellevue, WA, Nina B Masters Truveta, Inc , Bellevue, WA, Brianna M Cartwright Truveta, Inc , Bellevue, WA After CVS Caremark made anti-obesity semaglutide the preferred formulary option in July 2025, switching from anti-obesity tirzepatide surged from 0.6% to 9.7%, representing more than a 16-fold rise
Any skin changeswhether improvement or worseningshould be discussed with healthcare providers to determine appropriate management strategies and ensure changes are not indicative of adverse reactions requiring intervention
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Other proposed mechanisms include direct interaction with cell surface integrins (particularly alpha-2-beta-1), effects on iron metabolism through copper-iron regulatory interactions, and epigenetic modifications
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