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In the field of obesity, efforts are underway to use multi-omics and clinical data to predict individual responses to weight-loss interventions (including GLP-1RAs) and to precisely predict the risk of side effects (e.g., nausea) using algorithms like Phenomix GRS

Furthermore, redox alterations have bidirectional role in developing insulin resistance: H 2 O 2 has been shown in mice to attenuate insulin resistance while chronic ROS production via mitochondria and NOXes contribute to development of insulin resistance by pro-inflammatory cytokines (Loh et al

At the same time, the competitive paradigm is shifting beyond injectables

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In this way, the dosages, length of time under treatment, and supplementary measures will all be optimized