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However, when excess free Fe 2+ is present in the cell, ferritin is recruited and solubilized by specific cargo receptor recognition, and the released excess Fe 2+ in turn increases the formation of hydroxyl radicals through the Fenton reaction, inducing reactive oxygen species (ROS) production and increased susceptibility to cellular ferroptosis ( FIGURE 1 Lipid peroxidation is an important factor driving ferroptosis

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