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In Methods in Enzymology (ed

[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

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Physical therapy integration Synergistic benefits: Physical therapy provides mechanical stress stimulating tissue remodeling (Wolff's Law for bone, mechanical loading for tendon/ligament)