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Inducing ferroptosis by suppressing GPX4 Among the many members of the GPX family, GPX4 plays a pivotal role in the occurrence of ferroptosis and is the key regulator of its occurrence, mainly by inhibiting the formation of lipid peroxides

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Additionally, in high-fat-diet-induced obese mice, miR-194 overexpression through transcription factor 7-like 2(Tcf7l2) and forkhead box a1(Foxa1) inhibits proglucagon ( Gcg) and Pcsk1 gene transcription, ultimately suppressing GLP-1 synthesis in L-cells [33]

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