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214 The cardioprotective effects of semaglutide may be independent of its impact on weight, suggesting additional underlying mechanisms, including anti-inflammatory effects such as reductions in systemic inflammatory markers, which may contribute to cardiovascular benefit
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Even intravenous administration of GLP-1 at a physiological postprandial dose of 0.3 pmol/kg/min significantly slowed the rate of gastric emptying in healthy subjects, bringing them into a state of gastroparesis (Little et al., 2006)
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