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Chronic Stress : Long term physical or emotional stress increases oxidative stress, which can deplete the bodys natural antioxidant reserves

Thus, these comorbid conditions may further exacerbate the proinflammatory endothelial and monocyte phenotypes associated with preexisting G6PD-d, thereby compounding CVD risk 28,29,30

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This upregulates the expression of the autophagy marker LC3-II and reduces p62 accumulation, thereby enhancing the autophagy flux (34)

For instance, SIRT7 has been identified as a key player in the pathogenesis of immune-mediated intestinal inflammation, specifically in inflammatory bowel disease (IBD)