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Clinical studies examining oxidative stress biomarkers in individuals with migraine have found that the number of monthly headache days was negatively correlated with serum concentrations of two antioxidant enzymes, catalase and superoxide dismutase, and total antioxidant capacity while being positively correlated with serum levels of glutathione peroxidase 1, nitric oxide, and malondialdehyde (3739)

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These matched characteristics minimize confounding variables, suggesting that differences in GABA and CBF likely reflect PTSD pathophysiology rather than demographic or trauma-specific factors

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