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doi: 10.1056/NEJMoa1512693 95 Non-clinical review(S)

And rare social phenomena usually become one of two things: a source of danger or a source of status boosting

The hypothalamic-pituitary-adrenal (HPA) axis tightly regulates cortisol production, with the hypothalamus releasing corticotropin-releasing hormone (CRH), which stimulates the pituitary gland to secrete adrenocorticotropic hormone (ACTH), ultimately triggering cortisol release from the adrenal cortex