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doi: 10.1016/j.bbi.2011.08.007 160

Although it entered phase 1 trials in consideration as a treatment of ulcerative colitis, it has not been approved by the US Food and Drug Administration (FDA) for medical use, and data on human subjects is lacking

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Cancer 9 , e002121 (2021)

Deficiencies in the following can measurably impair histamine clearance: For those on highly restrictive low-histamine diets eating very few foods for extended periods deficiencies in these nutrients can actually compound the problem theyre trying to solve by further impairing the very enzymes responsible for histamine clearance