doi: 10.1038/ijo.2013.73 22 AsmarMAsmarASimonsenLGasbjergLSSparre-UlrichAHRosenkildeMMet al
While the mechanism is not yet proven, there is support for the idea that GLP-1 attenuates the ras homolog gene family, member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway, whose activation is known to reduce levels of occludin, claudin-5, and zonula occludens-1 (ZO-1), as well as promote disruption of endothelial tight junctions
Metabolism plays a key role in the origin or progression of many diseases, including neurodegenerative diseases, diabetes, and cancer [14]
GLP-1 microdosing allows these patients to access the metabolic benefits while minimizing gastrointestinal discomfort, fatigue, or other adverse reactions
In practice, I usually see better tolerance with half portions, softer preparation, and gradual increases