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Clinical Result: In SURMOUNT-1, participants taking the 15 mg dose lost an average of 20.9% of body weight over 72 weeks

Due to the formidable barrier posed by the SC, only a limited number of drugs are approved for transdermal delivery [228, 229]

Figure A shows that serum IGF-1 levels were lowest in a moderate protein diet and highest in a Western diet

A placebo-controlled study of 72 patients with type 2 diabetes found that oral administration of lipoic acid at doses of 600 mg/day, 1,200 mg/day or 1,800 mg/day improved insulin sensitivity by 25% after four weeks of treatment (58)

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