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Safety of L-Carnitine Carnitine is relatively well-tolerated but in high doses it may increase levels of trimethylamine-N-oxide (TMAO), a compound linked with an heart disease since it can increase blood pressure and the formation of plaque within the artery walls (atherosclerosis) (9)

Colluci and colleagues [150] used an in vitro model to suggest that carnitine supplementation in the elderly may stimulate osteoblast activity and decrease age-related bone loss

The flux through pathways that require nonesterified CoA, such as the oxidation of glucose, may be reduced if all the CoA available in a given cell compartment is esterified