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Weight-loss treatments should be personalized

Mouse and rat models show that signals through proinflammatory receptors, such as the receptor for advanced glycation end products and Toll-like receptors, are suppressed by GLP-1 receptor agonists, possibly by central nervous system GLP-1 actions resulting in immunomodulation through parasympathetic and opioid efferent activity

The authors note the meta-analysis did not include studies of lifestyle interventions and bariatric surgery, reducing the degree to which different weight loss approaches could be compared within the context of the study

Za razliku od prethodno navedenih neeljenih efekata, u 25% sluajeva mogua je pojava konstipacije, koja nije prolazna i esto zahteva povean unos tenosti, vlakana, probiotika, fizike aktivnosti, a ponekad i odlazak po savet lekara ili farmaceuta

In the cardiovascular outcomes trial, patients aged 75 years and older reported more fractures of the hip and pelvis on WEGOVY than on placebo