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Retrieved from This article was reviewed and approved by Lujain Alhassan, Bariatric Nutritionist, on 17 November 2025

Maintaining nerve cells and the nervous system

doi: 10.1089/thy.2023.0284

It is the first medication to meaningfully address both sides of the energy balance equation: | Medication | What It Reduces | What It Burns | Max Weight Loss | |-----------|----------------|---------------|-----------------| | Semaglutide | Appetite (GLP-1) | -- | ~15-17% | | Tirzepatide | Appetite (GIP + GLP-1) | Minimal | ~20-22% | | **Retatrutide** | **Appetite (GIP + GLP-1)** | **Calories (Glucagon)** | **~24%** | That additional glucagon column is why retatrutide achieved more weight loss in less time than either competitor

Semaglutide is not for people who are only looking to lose a small amount of weight for cosmetic reasons