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The honest answer from current literature: the oral berberine research base is robust, but that research does not automatically validate transdermal delivery of the same ingredient

If you do have more sensitive skin that requires a light glowy, hydration and a boost, its a great product

Lazzer S, Bedogni G, Agosti F, De Col A, Mornati D, Sartorio A

Cooksey RC, de Waard JH, Yakrus MA, Rivera I, Chopite M, Toney SR, Morlock GP, Butler WR

Consequently, researchers require improved receptor-selective analogues, advanced pharmacologic tools, and genetic knockout systems to isolate MC4-specific signaling contributions while minimizing cross-reactivity between receptor subtypes