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The dermis contains the highest concentration of these sensory nerve endings, which explains why the initial skin puncture typically causes the most noticeable sensation

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For laboratories, this enables experimental designs where receptor engagement is tracked across longer windows, and downstream marker programs are sampled at multiple timepoints under consistent exposure assumptions

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Prednisone is metabolized by the placenta, and is unlikely to cause fetal malformations, but increases the risk of diabetes and hypertension in the mother