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Discontinuation rates due to adverse effects were also higher with retatrutide being 16-17% compared with 2% with dulaglutide and 0-4% with placebo

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Notably, treatment with either 1,25(OH) 2 D 3 or the ferroptosis inhibitor ferrostatin-1 reduced the expression of senescence markers in D-galinduced osteoblasts, suggesting that VDR activation suppresses osteoblastic senescence by inhibiting ferroptosis ( Postmenopausal osteoporosis Osteoporosis factors related to aging are also implicated in postmenopausal osteoporosis ( Alu hypomethylation in blood cells is associated with decreased bone density in postmenopausal women ( Diabetic osteoporosis T2DM is characterized by insulin resistance and hyperglycemia

Saudi J Biol Sci 28:42244231

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