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It is often overexpressed in fibrotic lung disease, allergic airway disease, and in the stroma of several cancers (breast, colon, prostate, etc.), where it supports fibrosis, invasion, and metastasis

Research suggests these therapies may address different physiological mechanismsone targeting appetite signaling and the other supporting muscle protein synthesis

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AMH (anti-Mllerian hormone) reflects ovarian reserve and tends to decline naturally with age, supplements cannot dramatically reverse low AMH or create new eggs

However, some studies indicate an increased risk of fractures, possibly due to weight loss-associated reductions in bone mineral density (BMD)