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& Pickett, C

This mechanism plays a critical role in the cellular response to oxidative stress and the regulation of antioxidant gene expression, and it may also be significant in disease progression [148]

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Besides acute myeloid leukemia, BCAT1 is also activated in the blast crisis of chronic myelocytic leukemia (CML) (Hattori et al., BCKAs can be further catabolized by the multimeric BCKA dehydrogenase enzyme complex (BCKDH) (Figure 1)

2020: The year the FDA approved the first fixed-dose combination pill (Advil Dual Action) in the US