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doi:10.1007/s12020-019-02085-7 Barber TM, Hanson P, Weickert MO, Franks S

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Examination of electron transport chain function in muscle and fibroblast culture, histological and electron microscopy examination of muscle and other biomarkers of mitochondrial metabolism revealed a pattern consistent with the notion that PPA could be interfering with mitochondrial metabolism at the level of the tricarboxylic-acid cycle (TCAC)

Several studies have shown that LA supplementation significantly decreases hepatic lipid accumulation and function in a normal MCD diet and a hypercaloric MCD diet (Table 6)