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The main problem is that AMPs are easily hydrolyzed by proteases and they have certain hemolytic toxicity in vivo

Epiploic appendagitis is most commonly caused by torsion or thrombosis of an epiploic appendage, leading to ischemia, edema, aseptic inflammation, and eventual resorption by the peritoneal cavity [3, 4]

PubMed Central , Chronobiology International , vol

That would be an interesting thing to explore because the...so what I'm getting at here is I'm a scientist, obviously, you're a scientist and like to understand the mechanism and see solid data before you think something is true

From our experience, higher gauges like the 30-31G needles from Insumed and BD cause minimal pain, even though they take a few extra seconds to inject