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The weight-loss effects of Semaglutide, a long-acting GLP-1RA, are well-established,9 and this was confirmed in our elderly cohort

Early data suggests both medications primarily reduce fat mass, with proportionally smaller losses of lean tissue

This may be due to the fact that the expression level of SRD5A1 in the KO group is already very low, and finasteride has a limited inhibitory effect compared with the control group

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