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Several mechanistic links underlie this connection, primarily involving microbial metabolites, inflammatory responses, vagus nerve signalling, and neurotransmitter modulation

Consistently, the FA injection induced dramatic increases in serum creatinine and BUN levels, indicating impaired renal function, while these functional parameters associated with AKI were reduced by LA supplementation, indicating the amelioration of renal function

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In an embodiment, a subject with a weight related comorbidity and an initial BMI 27 kg/m 2 achieves weight loss of at least 17%