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SUBJECTS AND METHODS We performed a multicenter nonrandomized single-arm prospective clinical trial of outpatients receiving hemodialysis at Keio University Hospital and Murai Clinic, Japan
Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment
While the benefit of successful first in human trials can potentially be massive, every clinical trial should prioritise the safety and well-being of its participants before anything else
