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Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

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Animal blood samples have been recovered according to EU Directive 2010/63/EU for animal experiments

Findings imply that TB-500, through modulation of actin and cellular migration, may assist in reorganizing provisional matrix scaffolds