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An increase warrants attention, especially if combined with symptoms like fatigue or abdominal discomfort

191 This suggests that fats, proteins and glucose have a synergistic effect on GLP-1 secretion

Regarding metabolic parameters, GLP-1 RAs significantly improved triglycerides, markers of insulin resistance (HOMA-IR, two-hour insulin, ISSI and ISOGTT), and fasting and postprandial plasma glucose