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Some individuals may also experience digestive discomfort at higher intake levels

The trial's primary insulin-sensitivity endpoint was null across the whole group, with benefits appearing in subgroups such as people with low baseline Akkermansia and those with prediabetes ( Suenaert et al., 2026 )

Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome

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International Agency for Research on Cancer Handbook Working Group