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While our in vitro developability assessments were performed on a small cohort of target-specific, high-expression antibodies from each repertoire and requires validation in a larger, more unbiased subset to definitively attribute native pairing to gains in developability, the bioinformatic workflows employedparticularly our clustering-based clonal selection strategiessuggest that the selected antibodies should be representative in sequence and function of the larger target-specific diversity

In vitro studies using adipocyte precursor cell lines have investigated how this fragment influences adipogenic transcription factor expression, including PPAR and C/EBP, which are key regulators of the adipocyte differentiation programme

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doi: 10.1111/j.1365-2982.2012.01891.x 201 KomaroffALLipkinWI