This is one reason most IGF-1 LR3 protocols avoid late-evening dosing dosing close to bedtime is more likely to coincide with the natural overnight GH pulse
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Things like screens, bright lights, working late, shift work, wifi, stimulators, heavy eating, alcohol, medications, lack of exercise and so on can all disrupt the circadian rhythm and raise stress hormones
GHRH analogs like sermorelin or CJC-1295 with Ipamorelin require more careful consideration but are not strictly contraindicated
Therapeutic effects of batoclimab in Chinese patients with generalized myasthenia gravis: a double-blinded, randomized, placebo-controlled phase II study