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225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate

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Ellouk-Achard S, Levresse V, Martin C, Pham-Huy C, Dutertre-Catella H, Thevenin M et al

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However, GHRP-6's pronounced appetite stimulation and broader hormonal footprint, including cortisol and prolactin elevation at higher doses, make it a less refined option than newer secretagogues like ipamorelin