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50 The decline in the notochordal cell density negatively impacts the maintenance of a healthy nucleus pulposus

In mice, aneuploidy increased from approximately 15% to 43% with age, but SIRT2 overexpression lowered spindle defects and misalignment and increased pregnancy rates from 25% to 75% in transgenic females

An orthopedic evaluation, including MRI, is the appropriate first step before pursuing any alternative therapy

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