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In contrast, during chronic or infected wound states, the pH shifts to alkaline levels (pH 79) as a result of microbial activity 53,54

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Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WPT, Loria CM, Smith SC

Recognizing these factors explains why identical starting points often lead to different outcomes over time

It may not be advisable to file a terminal disclaimer because it risks the enforceability of the parent patent It may result in competitors having a lower bar of entry into the market occupied by the patent holders because they will only need to pursue the invalidation of one patent