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This directly relates to the question of does bottled water ever go bad, as the water itself doesnt spoil but the container can affect quality

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When considering PO-based stratification, changes in BCAAs and catabolites were more pronounced among children within the PO+ group, but only when analyzing erythrocytes, as stated before for acyl-carnitines

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High-dose protocols (e.g., 50,000 IU administered weekly or every two weeks) and lower daily doses (e.g., 2000 IU/day) have been evaluated, with generally favorable but not uniformly consistent effects on pain and biochemical markers