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4-(3-(Benzyloxy)phenyl)-2-ethylsulfinyl-6 (trifluoromethyl)pyrimidine (BETP) is such a small molecule that covalently attaches to C347 in the intracellular loop 3 near the beginning of the transmembrane helix 6 (TM6

The surgery restricts food intake by creating a smaller stomach pouch

"In just a few weeks I felt a noticeable difference in the clarity of my skin and I feel great." - Alex N

Due to the constitutive expression of this variant library, we predict that this population is likely representative of silent variants that exhibit WT-like p53 activity and are therefore dropped out of the population

3-5 Proposed mechanisms include both intraocular pressure (IOP)lowering effects and IOP-independent effects