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472 Following the publication of these new trials, a meta-analysis was performed using findings from six randomized controlled trials with follow-up periods of one to two years and a total of 21,800 participants who had experienced a heart attack or stroke or who had stable coronary artery disease

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Crucially, comprehensive drug safety testing in mice indicated no significant adverse effects on myocardial, liver, or renal function markers after 30 days of treatment, suggesting a favorable safety profile [2]