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Urea is secreted through urine, but becomes detectable in the blood when glomerular filtration rates drop
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The apparent lack of such a relationship for some drugs does not weaken the basic hypothesis but points to the need to consider the time course of concentration at the actual site of pharmacologic effect (see below)
Why Metformin Can Leave You Too Tired to Lose Weight If youve been on metformin for years, for insulin resistance, PCOS, or type 2 diabetes, and youre too drained to walk after dinner, cook at home, or stick with any weight-loss plan, a low vitamin B12 level could be part of why
& Rahwanto, E
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