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Patients who report a severe delayed immune-mediated reaction (eg, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome or toxic epidermal necrolysis, acute generalized exanthematous pustulosis, drug-induced nephritis or hepatitis) should subsequently avoid the culprit drug, as this can be regarded as a contraindication to future use

Its safety is supported by its natural presence in the body and homeostatic regulation, which prevents copper toxicity (Pickart, 2010)

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Turkish Journal of Biology