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In these cells, the GSH levels were significantly higher than those in A2780 cells (Figure 3 and Figure 4) and the drastic decrease in GSH by glutamate, a competitive inhibitor of the cystine uptake, indicates that system x c mainly contributes to the high level of GSH in A2780DDP cells

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Diabetic patients should have a baseline eye examination around the time of GLP-1/GIP agonist treatment initiation to determine the level of retinopathy and presence of DME

Antioxidant mechanisms include enhanced expression of molecules that can modulate ROS accumulation by both enzymatic and nonenzymatic meansGlutathione (GSH) is an antioxidant that acts as a free radical scavenger and a detoxifying agent in cells