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What to do next: Talk to your doctor about your interest in antioxidants

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Senescent Leydig Cell Elimination & Testosterone Restoration in Aged Mice (Aging / PMC, 2020) FOXO4-DRI Disrupts FOXO4-p53 in Senescent Leydig Cells and Improves Testicular Microenvironment A study published in Aging (and indexed on PMC) demonstrated that FOXO4 is specifically expressed in human Leydig cells, with nuclear translocation of FOXO4 in elderly men correlating with decreased testosterone synthesis

Levels drop significantly as you age, and research has found that this decline is connected to things like thinning skin, slower wound healing, and hair loss

They're the long-established standard of care, both FDA-approved, both backed by decades of clinical data