Weight loss of 5-10% can make a profound difference [25-28]
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In a recent study, increased LRP5 expression promoted the osteogenic effects of the Wnt/-catenin signalling pathway, with consequent effects on bone (Chen et al., 2022)
The study of 333,687 veterans compared 132,551 participants who were prescribed GLP-1s for their type 2 diabetes with 201,136 participants who were prescribed sulfonylureas, another treatment for diabetes, and followed the patients outcomes for up to three years
It helps stimulate insulin gene transcription, hence improving insulin production, lowering blood sugar levels, and protecting pancreatic beta cells