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Moreover, disruption to redox dysregulation is increasingly implicated as an important driver of neurodegeneration in the pathogenesis of many age-related neurodegenerative disorders, including ALS

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Figure 1 Ferroptosis, a recently identified form of programmed cell death, is characterized by elevated levels of reactive oxygen species (ROS) and iron-dependent lipid peroxidation ( + to Fe + occurs after cellular iron uptake through transferrin receptor 1 (TFR1)

This in vitro synergy confirmed that the interaction occurs at the somatotroph level, independent of hypothalamic factors, and reflects direct convergence of receptor signaling pathways on the GH secretory machinery