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Urolithiasis In a CV outcomes trial, 1.2% of WEGOVY-treated patients and 0.8% of patients receiving placebo reported urolithiasis, including serious reactions that were reported more frequently among patients receiving WEGOVY (0.6%) than placebo (0.4%)

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In others, the response may remain limited despite those changes

10.1590/S0004-27302013000900005 61

Since copper is a trace mineral required in minimal doses, excess intake can cause nausea, gastrointestinal issues, and other health problems