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Plant-derived phytochemicals show strong chemopreventive activity against breast cancer by selectively modulating important signaling pathways and offering a safer profile than many conventional treatments ( Figure 3 )

The association of IGF-1 and IGF-1R apparently leads to changes in metabolism, prevention of cell death (apoptosis), promotion of cell growth (hypertrophy), differentiation and cell division (hyperplasia), normal development, and even malignant growth

The evaluation of early, subclinical, changes at CV level induced by GLP-1Ra and SGLT2i will be key to unravel their cardioprotective effects [19, 20]

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Pharmacogenetics 4:225241 Schrder P, Khalvati M, Neustifter J, Gschlssl T (2008) Use of Phragmites australis for phytoremediation of organic compounds in municipal waste water treatment plants