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Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)
More help Considerations for Potential Applications of the AOP (optional) Addressess potential applications of an AOP to support regulatory decision-making.This may include, for example, possible utility for test guideline development or refinement, development of integrated testing and assessment approaches, development of (Q)SARs / or chemical profilers to facilitate the grouping of chemicals for subsequent read-across, screening level hazard assessments or even risk assessment
On 24 November 2025, Novo Nordisk reported that oral semaglutide had failed to slow Alzheimers disease in the EVOKE and EVOKE+ trials, which together enrolled 3,808 participants and stand as the largest evaluation of this drug class in any neurodegenerative condition [1]
Hunger-related neurons (HRP neurons) respond to immediate sensory stimuli and are possibly involved in predicting satiation, affecting meal size and meal end
Aging Cell 22 , e13979 (2023)
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