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At the renal level, these toxins induce direct cytotoxicity (mitochondrial dysfunction, DNA damage, epigenetic alterations), endothelial dysfunction (via VCAM1, ICAM1, tissue factor), and activation of both innate (macrophages, ILC3s) and adaptive (Th1/Th17/Treg dysregulation, Bcell modulation) immune responses

Gastrointestinal effects (e.g

doi:10.3945/ajcn.114.101964 44 Hultberg, B., Andersson, A., Masson, P., Larson, M

Temperature not exceeding 25 degrees centigrade

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