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Immunostaining showed that BACE1, APP, and A are closely co-localized with large motor neurons in the ventral horn of the spinal cord in AD mouse models and that A plaques are largely derived from the dystrophic presynaptic axonal terminals originating from glutamatergic neurons arising in the brain and projecting to spinal cord neurons (Li et al., 2013)

This helps reduce symptoms such as tiredness and/or lack of energy

- IGF-1 (trial data suggests no meaningful change

Each patient is different and may require different treatment to achieve the desired results

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