Sklyarov AY, Panasyuk NB, Fomenko IS
It is already established that Lewys bodies, which are composed of misfold -synuclein, contribute to cellular stress that can trigger various forms of cell death (Jiang et al., 2017
In archetypal DNA binding ZFPs, such as transcription factor IIIA (TFIIIA) and GATA-binding factor 1 (GATA-1, which binds the DNA sequence GATA), we see that a beta-hairpin and an alpha-helix are folded around a Zn ion and that it is the alpha-helix that binds with the major groove of DNA
We hypothesized that oxidation of GSH to glutathione disulfide (GSSG) in the epithelial lining fluid (ELF) of children with severe asthma would contribute to altered airway macrophage (AM) GSH homeostasis and AM cellular dysfunction
Additionally, this route can facilitate faster absorption into the bloodstream via the nasal mucosa, enabling a quicker onset of effects