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Reducing this medication burden while maintaining control represents a significant quality-of-life improvement

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This is consistent with experimental data in mice [17,18] and in the human study [19]

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In addition, basal-bolus insulin therapy was started (insulin glargine and lispro), reaching 156 IU/day (23% basal and 77% bolus, total insulin dose 2.23 IU/kg/day)

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